Polynucleotides: Plenhyage, Nucleofill, Nucleadyn

02/02/23Polynucleotides: Plenhyage, Nucleofill, Nucleadyn

What is Plenhyage, Nucleofill or Nucleadyn?

These are the new kids on the block in aesthetics. These highly purified polynucleotides (PN-HPT) from salmon sperm are in distilled into varying percentages and suspended in a water base. PN are fragmented DNA that when injected into the skin, draws water to the molecules and signals to your body to improve perfusion with vessels and then in turn fibroblasts are stimulated to create more of your own collagen, elastin and hyaluronic acid. You will also notice a reduction in inflammation of the skin. PNs optimise the extra cellular environment and stimulate tissue reconstruction and repair. This translates into fresher, revitalised and tighter skin. From now on I shall refer to Plenhyage, Nucleofill and Nucleadyn as Polynucleotides.


What can Polynucleotides treat and what results can you see?

I think the most exciting area Polynucleotides can be used is under the eyes. The tear trough, dark circles under the eyes and sagging skin can be really improved. It also helps with lumpy or sunken scars, acne scarring, hyperpigmentation, melasma, rosacea, inflammed skin, general signs of facial ageing, eyebrow and scalp hair loss. It’s also great for treating a wrinkly neck, décolleté, inner arms, thighs, and knees. The skin will have reduced pigmentation, improved skin quality, thickness and hydration. This takes a few months to become fully evident. 


Who can be treated by Polynucleotides?

As it is highly purified particles of DNA allergic reactions are not likely therefor can be safely injected into those who have allergies, even seafood allergies.


How long does a treatment take?

The actual injections will take around 30 minutes. However, 1 hour is allowed to prepare you for the procedure.


Are Plenhyage, Nucleofill or Nucleadyn injections painful?

Treatment is generally pain-free as the needles are exceptionally thin, but we can use a numbing cream if required. Cannula (a blunt tipped needle) is often used and as this delivers products under the skin with just one needle hole so is generally well tolerated.


How many sessions will I need?

At least 2 sessions 20 days apart. Some people may need 4 sessions. It depends on the degree of ageing your tissue has and your ability to create quality tissue when stimulated. It is so important to have a healthy diet, reduce smoking, reduce drinking alcohol and have a nutritious diet so you create good quality skin.


When will I see a difference?

Your skin quality will improve gradually as the tissues regenerate. Most notice a difference after 2-4 weeks, but things will continue to improve as this is a regenerative treatment. Full results can be expected about 3 months later.


How long will my results from Plenhyage, Nucleofill or Nucleadyn last?

For the best results repeat your treatment after 6-9 months. Even though you are banking collagen you will continue to age and so lose it again.


How much does Plenhyage, Nucleofill or Nucleadyn cost?

This is usually from £350 upwards. It depends on the existing condition of your skin and how many sessions you will require. We will confirm a price during your consultation. Prepaid courses may work out cheaper per session.


What is the difference between HA fillers and Polynucleotides? 

Dermal fillers simply add volume to the skin. They are “inert” volumisers in the tissues and the results are immediate. Fillers can stay in the tissues from anywhere between 6 months to years later, some remnants are there even up to 12 years later. Some people aren’t suitable for filler in the tear troughs if their skin is loose as HA draws in water and will create puffiness over time. Even in those who are suitable HA filler can move and create swelling years later.

Polynucleotides are different, in that they stimulate regeneration at the cellular level so it takes time to be seen visually and studies show volumes can be equivocal to HA fillers. It’s also true that polynucleotides stimulate your own skin and will show improved texture and appearance minimising pores and roughness. Combinations of PN and dermal fillers may be recommended for an overall holistic regeneration.


What is the difference between skinboosters and the Polynucleotides Plenhyage, Nucleofill or Nucleadyn?

It’s easy to be confused about the differences between these. It’s true both create dewy looking skin, however skin boosters are hyaluronic acid and amino acids. These work to add a soft volume and hydration effect. However, they do not have the same type of regeneration action.

Polynucleotides work to boost fibroblast production, induces tissue repair processes, reduces inflammatory process, regulates melanogenesis and promotes hydration in the skin. This means, yes, you will get dewy skin but also a build up of your own collagen that will last for years. However in both cases your skin will continue to age, so the aesthetic benefits will not last for years.


What is the difference between biostimulators and Plenhyage? 

In a way both of these create a reaction in the skin that will lead to improved collagen production. The common biostimulators used in the UK are Sculptra, Ellansé, Radiesse, HarmonyCa, Neuvia Stimulate etc. These dermal fillers have polymers like PLLA, PCL, CaHA (with or without hyaluronic acid) that over time degrade into carbon dioxide and water. Whilst they are present in the skin they set up a cascade of events to create wound healing collagen (type III) and often this transforms to a softer collagen (type I) over time. They can also produce volume in the skin, but the degree of volume varies. 

Plenhyage in contrast, stimulates the collagen, elastin and hyaluronic acid as well as some fat cells. The volume replacement is natural and younger looking.

Again, a biostimulator may be recommended alongside a PN for a more holistic result.


What is the difference between Profhilo and Plenhyage? 

Both Profhilo and Plenhyage will give radiance and glow to the skin. Profhilo is a mixture of hyaluronic acids that stimulate collagen whilst it is present in the skin for 28 days. The aesthetic benefits are there for around 4-6 months. There is some emerging evidence there may be a stimulation of good facial fat in that time. 

In contrast Plenhyage has no artificial hyaluronic acid and it stimulates your skin to produce collagen, elastin and it’s own HA resulting biorevitalisation of the skin.


What is biorevitalisation and regenerative medicine?

Regenerative medicine is the application of treatments developed to replace tissues damaged by age, injury or disease and is often referred to as bioregeneration. Bioremodelling means the structure of the tissue is altered. Often both of these processes co-exist.


Are there any problems or complications with Plenhyage?

Plenhyage is an injectable treatment so expect to have some bruising and possibly some stinging at the injection sites. If needles are used there can be little bumps for 48 hours after treatment so it may be best to avoid work until they settle. 

These very pure DNA particles in a water solution have very little chance of creating an allergic reaction or delayed reactions like nodules or biofilms. These are problems that can occur with all types of dermal fillers including HA fillers, biostimulators and Profhilo. The other fantastic thing is that there is no chance of vascular occlusion (blocked artery) because these tiny DNA fragments in water mimic exactly what is already in your blood stream. There is no gel, so blockages are very unlikely.


How do I book in for a treatment?

My private clinic is 1/2 way between Chester and Wrexham in a countryside setting with lovely gardens. I have clinical experience spanning over 25 years that includes aesthetics and dermatology. I give honest trustworthy advice on what will deliver results. Click on booking link or call us on 07711190079 to book for a consultation to see what treatments are suitable for your concerns.



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