Polynucleotides like Plenhyage, Plinest & Nucleofill

16/05/23Polynucleotides like Plenhyage, Plinest & Nucleofill

What are Polynucleotides (PNs)?

These are natural DNA molecules extracted from salmon or trout sperm that are so purified they can even be used in those with fish allergy. This product is injected into the skin and has been used since the 1950s for burn and wound healing.


How do they work?

They create a surge of fibroblast activity. These cells create collagen and elastin that are the building blocks of plump and resilient skin. They also produce lots of hydration (hyaluronic acid) in the skin. 


What areas can be treated?

PNs are particularly great around the eyes and mouth, as these areas are prone to lost elasticity as you age. Aged, scarred and stretch-marked skin responds really well to the tightening and moisturising effects of PNs. This lady had 2 treatments however better results are seen if 2-4 treatments are given.


Is it painful to have this treatment?

As really fine needles or cannulas are used there is minimal discomfort. However topical numbing cream is usually administered prior to injection.


How long do the results last?

Results last 6-9 months but this will depend on your lifestyle and rate of aging. 


What is the aftercare?

Strict application of SPF for 2-3 weeks. No makeup is advised for 12 hours. No lasers or excess heat for 3 weeks.


Are there any contraindications?

Do not use if you are pregnant or intending pregnancy. Even those allergic to fish can have this treatment without problems. The long-term data collected over 70 years show that there are no problems in using this product even in those with autoimmune conditions. 


Are there any side effects.

As with any injections expect redness, swelling and bruising. 


How much does it cost?

This depends on the advice given at your consultation. Procedural costs are from £350 upwards. 


How do I book in?

If you are a new patient please book for a consultation for a detailed assessment and treatment plan. 

My private clinic is 1/2 way between Chester and Wrexham in a countryside setting. I have 25 years of experience as a medical doctor including GP, aesthetics and dermatology. I give honest trustworthy advice on what will deliver results. Click on booking link or call on 07711190079 

Click here to book in 


Do you want to achieve a natural and more
youthful appearance? Book a consultation
with Dr K in her award winning clinic

Contact me today